In a mixing bowl, combine ground beef with garlic powder, onion powder, salt, and black pepper. Divide into two portions and shape into patties.

Preheat a non-stick skillet on medium-high heat for about 3 minutes and lightly grease with oil or butter.

Place one patty onto the skillet and top with a flour tortilla. Press down firmly with a spatula to smash it.

Flip the quesadilla so the tortilla side is down, sprinkle cheese over the patty, and cook for an additional minute.

Fold the quesadilla in half, cook until golden brown, slice into wedges, and serve with toppings.